MALDI 2^4+1 Factorial Example

We use data from a currently on-going factorial design experiment involving the matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOFMS) analysis of synthetic polymer mixtures. While many variables are in a MALDI experiment are critical, only the quantity of the four different analyte polymers in a quaternary mixture are used in a 2^4+1 factorial design- other variables, including the quantity of matrix (as matrix-to-analyte ratio), quantity of cationization reagent (NaTFA), laser power, instrument settings, etc. are all held constant.

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